Credit: Correspondence to - Laurence Albiges - Laurence.ALBIGES@gustaveroussy.fr The cover for issue 49 of Oncotarget features Figure 4, " CART-Tree analysis for overall survival in IMDC intermediate risk group," by Guida, et al.recently published in " A multivariable Cox model with backward selection procedure and a Classification and Regression Tree analysis were performed to identify which prognostic factors were associated to OS in IR patients. Median OS for patients with PLT > UNL was 18 months versus 29 months for patients with normal PLT count. The selection of PLT count was confirmed on bootstrap samples and was also selected for the first split of the CART-tree analysis.