E-Mail IMAGE: MEK inhibitor response correlates with basal subtype. Average and standard deviation for DSS3 response to (A) Trametinib, (B) TAK-733, (C) Normalized MEK inhibitors, and (D) Average drug response, grouped by... view more Credit: Correspondence to - Matthew B. Soellner - soellner@umich.edu and Sofia D. Merajver - smerajve@med.umich.edu Oncotarget recently published in " MEK is a promising target in the basal subtype of bladder cancer" by Merrill, et al. which reported that while many resources exist for the drug screening of bladder cancer cell lines in 2D culture, it is widely recognized that screening in 3D culture is more representative of in vivo response.