Updated: Systemic effects included headache, fatigue, chills and shiver, diarrhoea, fever, arthralgia, myalgia, and nausea. Share Article AAA Covishield vaccine vial at the COVID-19 vaccination centre in Coimbatore on Tuesday April 27, 2021. | Photo Credit: PERIASAMY M Systemic effects included headache, fatigue, chills and shiver, diarrhoea, fever, arthralgia, myalgia, and nausea. One in four people experience mild, short lived systemic side effects after receiving the COVID-19 preventive by Oxford-AstraZeneca (ChAdOx1 nCoV-19) vaccine — known as Covishield in India — with headache, fatigue and tenderness the most common symptoms, according to a study published in the Lancet Infectious Diseases journal. The researchers from King's College London in the U.K. also found that most systemic side effects — meaning side effects excluding where the injection took place — peaked within the first 24 hours following vaccination and usually lasted 1-2 days.