Children had a median of seven concurrent symptoms, and most children (about 76%) took 10 or more medications. Their median global symptom score (GSS, which ranges from 1 to 100) was 12.1. Per every GSS increase of 10 points, a 12% (95% CI 4%-19%) higher medication count was seen, adjusted for age and number of complex chronic conditions. “These findings suggest that children with severe neurological impairment reportedly experience substantial symptom burdens and that higher symptom scores are associated with increased medication use,” Feinstein and colleagues wrote. “Paired symptom-medication data may help clinicians identify targets for personalized symptom management, including under-recognized or undertreated symptoms.” For children who cannot self-report symptoms, no system exists to assess multiple symptoms and their association with medication use, they noted.