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Polypharmacy Linked to High-Distress Symptoms in Children with Severe Neurologic Impairment


Children had a median of seven concurrent symptoms, and most children (about 76%) took 10 or more medications. Their median global symptom score (GSS, which ranges from 1 to 100) was 12.1. Per every GSS increase of 10 points, a 12% (95% CI 4%-19%) higher medication count was seen, adjusted for age and number of complex chronic conditions.
“These findings suggest that children with severe neurological impairment reportedly experience substantial symptom burdens and that higher symptom scores are associated with increased medication use,” Feinstein and colleagues wrote. “Paired symptom-medication data may help clinicians identify targets for personalized symptom management, including under-recognized or undertreated symptoms.”
For children who cannot self-report symptoms, no system exists to assess multiple symptoms and their association with medication use, they noted. ....

United States , Abigail Musial , Joanna Thomson , James Feinstein , University Of Colorado School Medicine , Cincinnati Children Hospital Medical Center , Pharmaceuticals For Children , Colorado School , Cincinnati Children , Hospital Medical Center , Best Pharmaceuticals , Children Act , Memorial Symptom Assessment Scale , ஒன்றுபட்டது மாநிலங்களில் , பாங்கி இசை , ஜொவந தாம்சன் , ஜேம்ஸ் ஃபைன்ஸ்டீன் , பல்கலைக்கழகம் ஆஃப் கொலராடோ பள்ளி மருந்து , ஸிந்ஸந்யாடீ குழந்தைகள் மருத்துவமனை மருத்துவ மையம் , மருந்துகள் க்கு குழந்தைகள் , கொலராடோ பள்ளி , ஸிந்ஸந்யாடீ குழந்தைகள் , மருத்துவமனை மருத்துவ மையம் , சிறந்தது மருந்துகள் , குழந்தைகள் நாடகம் , நினைவகம் அறிகுறி மதிப்பீடு அளவு ,

Pain, Insomnia Frequent in Children with Severe Neurologic Impairment


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Children with severe central nervous system impairment including intractable seizures, cerebral palsy, hydrocephalus, or neurodegenerative processes had multiple, concurrent high-distress symptoms, and those symptoms were tied to increased medication use, a single-center study suggested.
Irritability (65%), insomnia (55%), and pain (54%) were the most prevalent symptoms reported by parents, said James Feinstein, MD, MPH, of the University of Colorado and Children s Hospital Colorado in Aurora, and co-authors in
Higher symptom burdens were linked to increasing polypharmacy most children in the study were taking at least 10 medications though only 61% of those affected by pain were prescribed an analgesic, the researchers noted. ....

United States , Judy George , Joanna Thomson , James Feinstein , Abigail Musial , University Of Colorado , Hospital Colorado , Cincinnati Children , Memorial Symptom Assessment Scale , Medpage Today , ஒன்றுபட்டது மாநிலங்களில் , ஜூடி ஜார்ஜ் , ஜொவந தாம்சன் , ஜேம்ஸ் ஃபைன்ஸ்டீன் , பாங்கி இசை , பல்கலைக்கழகம் ஆஃப் கொலராடோ , மருத்துவமனை கொலராடோ , ஸிந்ஸந்யாடீ குழந்தைகள் , நினைவகம் அறிகுறி மதிப்பீடு அளவு ,