Scientists uncover key to enhancing cancer-killing T cells :

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.

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Jordy Saravia , Peipei Zhou , Shondra Pruett Miller , Hongbo Chi , Hongling Huang , Nicole Chapman , Jonp Connelly , Xiang Sun , Zhao Shi , Cancer Center Support Grant , National Institutes Of Health , Jude Children Research Hospital , Jude Department Of Immunology , Jude Children , Research Hospital , Jude Department , Sujing Yuan , Seon Ah Lim , National Institutes , Cancer , Fell , T Cell , Ntigen , Flood , One , Bone Marrow , Ancer Immunotherapy , Children , Chimeric Antigen Receptor , Rispr , Efficacy , Exhaustion , Gene , Ene Expression , Hospital , Immune System , Mmunology , Immunotherapy , Mh , Reclinical , Eceptor , Research , Technology , Ranscription , Transcription Factors , Humor ,