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T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.
Immunologists map unknown biological machinery to produce memory T cells Immunologists at St. Jude Children's Research Hospital have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses, and tumor cells. The findings have multiple implications for how the adaptive immune system responds to infections to generate such memory T cells. The experiments revealed mechanisms that inhibit the development of the long-lived memory T cells that continually renew to protect the body over time. Blocking these inhibitory mechanisms with...
From left: Hongbo Chi, Ph.D., Hongling Huang, Ph.D., and PeiPei Zhou, Ph.D., all of St. Jude Immunology, have mapped the previously unknown biological...