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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation. Within each cell’s nucleus, MIT researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.
Spotlight on Dr. Manu Setty. Dr. Setty takes a multi-disciplinary approach to develop computational methods that make it possible to analyze and understand today’s enormous datasets. In particular, he focuses on the complex genetic interactions that govern cell-fate choice, or how non-specialized cells choose to become cells with specialized functions.
For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published in Science Advances,...
Pattern Formation and Cell Fate in Plant Development Arabidopsis thaliana - a model organism for plant genetics. Image Credit: Tomas Vynikal/Shutterstock.com The role of genetics In developmental cell biology, the phrase “pattern formation” is used in reference to the propagation of complex organizations of cell fates in time and space. Pattern formation is mainly controlled via genes, such as homeobox type genes. The vital role of genetics in pattern formation is a facet of morphogenesis: the creation of diversified anatomies from similar genes, which are now being examined in studies co...
Aging published "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" which reported that cellular senescence is a cell fate...