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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation. Within each cell’s nucleus, MIT researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.
Using a new technique, MIT researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
MIT scientists find that loops in the genome may be much rarer and shorter-lived than previously thought, lasting only tens of minutes, which suggests current theories of how loops influence gene expression may need to be revised.