SkylineDx, Oncode Institute and Utrecht Holdings sign license agreement for innovative algorithm RAINFOREST News provided by Share this article Share this article ROTTERDAM, Netherlands and SAN DIEGO, Feb. 23, 2021 /PRNewswire/ -- Today, SkylineDx announces to have signed a license agreement with Oncode Institute and Utrecht Holdings on a shared patent covering the innovative algorithm RAINFOREST. This algorithm is based on Random Forest, a specific machine learning method, and is able to identify subgroups of patients that will benefit more than the population as a whole from a certain treatment [2]. The performance of this algorithm is demonstrated on a dataset from a phase III (last phase of medicine research) colorectal cancer study. This study did not show any benefit for the drug (Cetuximab) under investigation, meaning that patients had the same risk of progressing whether they would have received Cetuximab or not. RAINFOREST, however, was able to identify a subgroup of patients (27.7%) that did significantly benefit and had a lower risk of progression if they would have been treated with the new drug.