If you've been fully vaccinated, you can travel across the country without having to get tested or self-quarantine after travel and you don't have to get tested before leaving the United States, unless it's required by where you're going, or self-quarantine when coming back to the country, Get our free mobile app If you've been fully vaccinated, and wait the two weeks the doses take to set in, it opens up the door to doing more things in certain cases but in no way should you let your guard down, the CDC explains, and it doesn't mean you can do whatever you want, if there are restrictions in place by a particular state or your doctors office or work, you may have to get tested or self-quarantine.