The FBI’s Combined DNA Index System (CODIS) Hits Major Milestone On April 21, 2021, one of the most successful investigative tools available to U.S. law enforcement reached a major milestone: the 20 millionth DNA profile was contributed to the national DNA database via the CODIS software. CODIS links unknown DNA left during the commission of a crime to offenders who are legally required to provide samples for the database. The FBI introduced the national DNA database in 1998. The program began with nine states and soon expanded to all 50 states. CODIS is currently installed in 203 federal, state, and local participating laboratories in the United States. It is used to share DNA profiles across all 50 states, the District of Columbia, Puerto Rico, federal law enforcement agencies, and the Department of Defense. The CODIS software is also used by 58 countries for their own law enforcement identification purposes; the international databases are not connected to the national DNA database in the United States.