The natural history of untreated pulmonary tuberculosis in a

Stages of tuberculosis disease can be delineated by radiology, microbiology, and symptoms,
but transitions between these stages remain unclear. In a systematic review and meta-analysis
of studies of individuals with untreated tuberculosis who underwent follow-up (34
cohorts from 24 studies, with a combined sample of 139 063), we aimed to quantify
progression and regression across the tuberculosis disease spectrum by extracting
summary estimates to align with disease transitions in a conceptual framework of the
natural history of tuberculosis.

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