The Issue Brazil and the United States enjoy a strong relationship which includes cooperation in various areas, including trade, security, education, science and technology, and more. However, the current level of exchange in these areas does not accurately reflect the strategic importance of the relationship for the two largest democracies and economies in the Western Hemisphere. The creation of a binational organization would advance and institutionalize the Brazil–U.S. relationship by promoting innovative ways of thinking and inviting a new, collaborative, and transformational approach to partnership development. Introduction Brazil and the United States have enjoyed a strong, longstanding diplomatic relationship that presently includes cooperation on issues such as trade and investment, security, defense technology, space exploration, 5G infrastructure, the environment, and education. However, the current level of exchange in these areas does not accurately reflect the strategic importance of the relationship for the two largest democracies and economies in the Western Hemisphere. Brazil and the United States need an institution on the scale and impact of the German Marshall Fund of the United States (GMF) or the Luso-American Development Foundation (FLAD) to deepen, catalyze, and sustain strategic partnerships among their civil societies, public sectors, and private sectors. The creation of a binational institution to advance the Brazil–U.S. relationship would demonstrate each country’s importance to the other and allow for additional avenues of cooperation and collaboration beyond those already established. Moreover, the Brazil–U.S. binational institution would be the first entity to cover such themes as sustainable development, entrepreneurship and innovation, social business, impact investing, and corporate social investment as part of its strategic focus to promote economic growth, create jobs, and encourage sustainable development for both countries.