report fever, stiff muscles, or confusion, which may mean a life-threatening reaction, or uncontrollable muscle movements, may be permanent. side effects may not appear for several weeks. metabolic changes may occur. movement dysfunction, restlessness, sleepiness, stomach issues are common side effects. when bipolar i overwhelms, vraylar helps smooth the ups and downs. it's not getting in my way.? i had enough! joint pain, swelling, tenderness... ...much better. my psoriasis, clearer... cosentyx works on all of this. four years and counting. so watch out. i got this! watch me. real people with active psoriatic arthritis are feeling real relief with cosentyx. cosentyx is a different kind of targeted biologic.