Tri-State residents 'go with the flow' as Ohio River rises The Ohio River is set to crest sometime Wednesday night, putting homes in low-lying areas at risk of flooding. Most people who live in flood-prone areas say they are watching the river closely, but theyâre grateful things arenât projected to be nearly as bad as in years past. and last updated 2021-03-04 11:11:51-05 CINCINNATI â The Ohio River is set to crest sometime Wednesday night, putting homes in low-lying areas at risk of flooding. Most people who live in flood-prone areas say they are watching the river closely, but theyâre grateful things arenât projected to be nearly as bad as in years past.