The Cancer-Compromised Genome The Graduate College is pleased to present the Teams Live Event: The Cancer-Compromised Genome, a lecture by University Scholar Gary S. Stein, Ph.D. on Monday, March 22, 2021 at 4:30 pm. The event can be joined at http://go.uvm.edu/universityscholars. A mechanistic and clinical challenge is understanding and treating cancer as a disease of compromised cellular and molecular organization. Cancer onset and progression are functionally associated with aberrant genetic (DNA-encoded) and epigenetic (non DNA-encoded) mechanisms that influence the transmission and retention of regulatory information during cell division. Cancer cells must sustain their compromised genome structure (deletions, amplifications, rearrangements), epigenetic status and function—otherwise cancer would be cured by cell division. Each regulatory component of gene expression is linked to architectural organization of regulatory machinery in the cell nucleus. Fidelity of nuclear structure-gene expression interrelationships are obligatory for physiologically responsive control and provide novel options for high-resolution tumor diagnosis and therapeutic interventions with specificity and minimal off-target consequences.