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UVM gets $9 million to explore epigenetics of breast cancer | Vermont Business Magazine

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Larner College of Medicine faculty Gary and Janet Stein are principal investigators on a new $9 million grant from the National Cancer Institute to explore the epigenetics of breast cancer with the goal of finding new drug targets. (Photos: Sally McCay, Larner College of Medicine)
Project to Identify New Targets for Drug Treatment That Could Prevent or Halt Disease
Vermont Business Magazine A team of University of Vermont scientists and physician investigators at the UVM Cancer Center and the Northern New England Clinical and Translational Research Network has been awarded a $9 million, five-year grant from the National Cancer Institute (NCI) to investigate the underlying causes of breast cancer with the goal of identifying new cellular-level targets that could be treated with drugs to prevent the disease or halt its progression. ....

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University Scholar Lecture Series – Gary S. Stein, Ph.D.

The Cancer-Compromised Genome
The Graduate College is pleased to present the Teams Live Event: The Cancer-Compromised Genome, a lecture by University Scholar Gary S. Stein, Ph.D. on Monday, March 22, 2021 at 4:30 pm. The event can be joined at http://go.uvm.edu/universityscholars.
A mechanistic and clinical challenge is understanding and treating cancer as a disease of compromised cellular and molecular organization. Cancer onset and progression are functionally associated with aberrant genetic (DNA-encoded) and epigenetic (non DNA-encoded) mechanisms that influence the transmission and retention of regulatory information during cell division. Cancer cells must sustain their compromised genome structure (deletions, amplifications, rearrangements), epigenetic status and function otherwise cancer would be cured by cell division. Each regulatory component of gene expression is linked to architectural organization of regulatory machinery in the cell nucleus. Fidelity of ....

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