Reply At least 70 percent of Colorado residents need to be vaccinated against COVID-19 before the state can safely roll back all public health restrictions, according to CU research. (Shutterstock) Colorado is nearly halfway to safely returning to normal, according to the latest public health data and a University of Colorado study released Wednesday. At least 70 percent of Coloradans will need to get vaccinated against COVID-19 before the state can safely roll back all public health restrictions, CU researchers said. Around 30 percent of our state's population are fully immunized, according to the latest public health data. But some Coloradans are choosing to hold off on getting vaccinated, health officials say.