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Guillain-Barré Case Reported After Covid-19 Vaccination


Apr 9, 2021
Available evidence does not support causal inference
Clinical details of a participant in a Covid-19 vaccine trial who developed Guillain-Barré syndrome (GBS) after vaccination were published in
Two cases of GBS, one in the active and one in the placebo arm, were reported in the Ad26.COV2.S (Johnson & Johnson) Covid-19 vaccine trial data. “Our patient in the vaccine arm did not have any clinical features differentiating her from patients with typical GBS,” wrote Anthony Amato, MD, and co-authors, all of Brigham and Women’s Hospital, Boston.
“From the available evidence, it is not possible to draw causal inferences about the association of Covid-19 vaccination and the development of GBS,” they added. ....

United States , Paul Smyth , Joep Killestein , Dennis Bourdette , Strongbridge Pharma , S Johnson Covid , Anthony Amato , Oregon Health Science University In Portland , Vrije University Amsterdam , Oregon Health , Science University , Contributing Writer , ஒன்றுபட்டது மாநிலங்களில் , பால் ஸ்மித் , அந்தோணி அமடோ , ஓரிகந் ஆரோக்கியம் அறிவியல் பல்கலைக்கழகம் இல் போர்டிலந்ட் , ஓரிகந் ஆரோக்கியம் , அறிவியல் பல்கலைக்கழகம் ,

Donor Heart Preserver Survives Review by FDA Advisors


email article
The TransMedics Organ Care System (OCS) Heart System got closer to regulatory approval as it emerged victorious from a contentious FDA advisory committee meeting.
Members of the agency s Circulatory System Devices Panel voted 12-5 (with one abstention) that the OCS Heart System s benefits outweigh its risks as a device that could potentially widen the pool of donor hearts perhaps even reduce waitlist times by preserving non-standard donor hearts longer than traditional cold storage during transport.
Panelists voting in favor did so despite complaining of flimsy safety and effectiveness data in the PROCEED II, EXPAND, and EXPAND CAP studies. ....

United States , Keith Allen , Nicole Lou , Murray Kwon , Jason Connor , Waleed Hassanein , George Vetrovec , Joaquin Cigarroa , School Of Medicine , Oregon Health Science University In Portland , Health Pauley Heart Center , Circulatory System Devices Panel , Transmedics Organ Care System , Heart System , Pauley Heart Center , Kansas City , Oregon Health , Science University , Medpage Today , ஒன்றுபட்டது மாநிலங்களில் , மிச Ou ரி , கேய்ட் ஆலன் , நிக்கோல் லூ , முர்ரே க்குவொன் , ஜேசன் இணைப்பான் , வாலீட் ஹஸ்ஸனேன் ,

Increased Physical Activity Attenuated Cognitive Decline in Parkinson's Patients with APOE Ε4


Increased physical activity attenuated
APOE ε4-related vulnerability to early cognitive decline in Parkinson’s disease (PD) patients, a retrospective cohort study found.
“This study provides Class II evidence that increased physical activity was associated with decreased
APOE ε4-related early cognitive decline in PD patients,” wrote Jin-Sun Jun, MD, of Hallym University in Seoul, Korea, and co-authors in
“This protective effect did not appear to be mediated by striatal dopaminergic function,” they added.
Jun and colleagues analyzed data from the Parkinson’s Progression Markers Initiative. All 173 patients (baseline mean age: 63 years) were recently diagnosed with idiopathic PD and had abnormal dopamine transporter (DAT) imaging while untreated. In all, 27% were ....

Soult Ukpyolsi , South Korea , United States , Jacob Raber , Paul Smyth , Jin Sun Jun , National Research Foundation , Oregon Health Science University In Portland , Parkinson Progression Markers Initiative , Hallym University , Ministry Of Science , Progression Markers , Physical Activity Scale , Montreal Cognitive Assessment , Oregon Health , Science University , Contributing Writer , தெற்கு கொரியா , ஒன்றுபட்டது மாநிலங்களில் , ஜாகோப் ரப்பர் , பால் ஸ்மித் , ஜின் சூரியன் ஜூன் , தேசிய ஆராய்ச்சி அடித்தளம் , ஓரிகந் ஆரோக்கியம் அறிவியல் பல்கலைக்கழகம் இல் போர்டிலந்ட் , பார்கின்சன் ப்ரோக்ரெஶந் குறிப்பான்கள் முயற்சி , அமைச்சகம் ஆஃப் அறிவியல் ,