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NANOBIOTIX Partners With LianBio to Develop and Commercialize Potential First-in-Class Radioenhancer

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11-May-2021
NANOBIOTIX Partners With LianBio to Develop and Commercialize Potential First-in-Class Radioenhancer NBTXR3 Across Tumor Types and Therapeutic Combinations in China and Other Asian Markets
LianBio to collaborate in the development of NBTXR3, and contribute to enrollment in five future global registrational studies across several tumor types and therapeutic combinations including immunotherapy
Supports the expansion of global phase III registrational study in head and neck cancer into Greater China, with longer term strategic alignment across multiple tumor indications and therapeutic combinations
PARIS & CAMBRIDGE, Mass. & SHANGHAI & PRINCETON, N.J. (BUSINESS WIRE) $NBTX#LianBio Regulatory News:
NANOBIOTIX (Euronext : NANO – NASDAQ: NBTX), a late-stage clinical biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer, today a ....

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Curis Reports Updated Data in Two Abstracts for CA-4948 Accepted for Presentation at the European Hematology Association 2021 Virtual Congress

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LEXINGTON, Mass., May 12, 2021 /PRNewswire/ Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, today announced that two abstracts for CA-4948, a novel, small molecule IRAK4 inhibitor, have been accepted for oral and poster presentation at the European Hematology Association 2021 Virtual Congress (EHA), which will be held virtually from June 9-17, 2021. The abstracts include updated data from a February data-cut for its ongoing open-label, single arm, Phase 1/2 study of CA-4948 in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS).
We are very pleased to report this clinical update on our first-in-class IRAK4 kinase inhibitor, CA-4948, as an anticancer agent for patients with acute myeloid leukemia and myelodysplastic syndromes for whom multiple prior lines of therapy have been unsuccessful, said James Dentz ....

United States , James Dentzer , Guillermo Garcia Manero , University Of Texas Md Anderson Cancer Center , Drug Administration , European Hematology Association , Md Anderson Cancer Center , Curis Inc , Exchange Commission , Department Of Leukemia , Roche Group , Virtual Congress , Biology Translational Research , Chief Executive Officer , Dose Escalation Trial , Novel Oral , Acute Myelogenous Leukemia , Myelodysplastic Syndrome , Interim Report , Antitumor Effects , Human Acute Myeloid Leukemia , Translational Research , Myelodysplastic Syndromes , Orphan Drug Designation , Looking Statements , Securities Litigation Reform Act ,

Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy

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Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) plays an important and previously unknown role in blocking a form of cell death called ferroptosis, according to a new study published today in Nature by researchers at The University of Texas MD Anderson Cancer Center. Preclinical findings suggest that targeting DHODH can restore ferroptosis-driven cell death, pointing to new therapeutic strategies that may be used to induce ferroptosis and inhibit tumor growth.
“By understanding ferroptosis and how cells defend against it, we can develop therapeutic strategies to block those defense mechanisms and trigger cell death,” said senior author Boyi Gan, Ph.D., associate professor of Experimental Radiation Oncology. “We have discovered that DHODH plays a key role in defending against ferroptosis and shown that we can exploit this vulnerability with clinic ....

New York , United States , University Of Texas , Li Zhuang , Shiqi Wu , Hyemin Lee , Mashav Poyurovsky , Pranavi Koppula , Xiaoguang Liu , Yilei Zhang , Kellen Olszewski , Yuelong Yan , Bingliang Fang , Chao Mao , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Kadmon Corporation , Md Anderson Moon Shots Program , Boyi Gan , Experimental Radiation , National Institutes , Lung Cancer , Guang Lei , Experimental Radiation Oncology , Md Anderson Cancer Center , University Of Texas ,

MD Anderson and Broad Institute Launch Translational Research Platform Focused on Rare Cancers

MD Anderson and Broad Institute Launch Translational Research Platform Focused on Rare Cancers
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The University of Texas MD Anderson Cancer Center and the Broad Institute of MIT and Harvard launched a translational research platform to study rare cancers and develop a first-of-its-kind resource for the scientific community.
The joint initiative will create a catalog of rare cancer models and provide a data resource to accelerate the identification of therapeutics to treat patients diagnosed with rare tumor types.
The National Cancer Institute defines a rare cancer as one with fewer than 40,000 new cases per year. Cumulatively, rare cancers account for roughly one-quarter of all cancer cases and cancer deaths, but the low incidence of each different type of rare tumor presents a significant challenge to efforts to identify effective therapeutic approaches. ....

United States , Timothy Heffernan , William Sellers , Broad Cancer Program , Broad Institute , University Of Texas Md Anderson Cancer Center , National Cancer Institute , Rare Tumor Initiative , Cancer Center , Therapeutics Discovery , Cancer Cell Line Factory , Cancer Dependency Map , ஒன்றுபட்டது மாநிலங்களில் , தீமோத்தேயு ஹெஃபர்னன் , வில்லியம் விற்பனையாளர்கள் , பரந்த புற்றுநோய் ப்ரோக்ர்யாம் , பரந்த நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் மையம் , சிகிச்சை கண்டுபிடிப்பு , புற்றுநோய் சார்பு வரைபடம் ,

Smith: Democrat plan on drug costs will stifle innovation

Smith: Democrat plan on drug costs will stifle innovation
Lamar Smith, For the Express-News
May 12, 2021
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This bill would be disastrous for anyone who needs prescription medicines.
The first casualties will be those who lose access to the latest lifesaving treatments for cancer and other diseases. The Democrats’ bill unwinds a carefully constructed incentive structure underpinning medical innovation, with the certain result of incalculable hardship due to the cures, treatments and vaccines that will never be developed.
Making sure Americans can afford their prescriptions is a vital national priority. But this legislation would only ensure less innovation and more Americans being deprived of new and necessary medicines. I hope my former colleagues reject this partisan exercise and work together on real solutions. ....

United States , United Kingdom , University Of Texas Md Anderson Cancer Center , International Market , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , சர்வதேச சந்தை ,