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Study clarifies the role of collagen during pancreatic cancer development

Study clarifies the role of collagen during pancreatic cancer development
Contrary to long-held beliefs, Type I collagen produced by cancer-associated fibroblasts may not promote cancer development but instead plays a protective role in controlling pancreatic cancer progression, reports a new study from researchers at The University of Texas MD Anderson Cancer Center. This new understanding supports novel therapeutic approaches that bolster collagen rather than suppress it.
The study finds that collagen works in the tumor microenvironment to stop the production of immune signals, called chemokines, that lead to suppression of the anti-tumor immune response. When collagen is lost, chemokine levels increase, and the cancer is allowed to grow more rapidly. The research was published today in ....

United States , Raghu Kalluri , Emily Henderson , University Of Texas Md Anderson Cancer Center , Cancer Biology , Senior Author , Pancreatic Cancer , Immune Response , ஒன்றுபட்டது மாநிலங்களில் , ரகு கல்லூரி , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , புற்றுநோய் உயிரியல் , மூத்தவர் நூலாசிரியர் , கணையம் புற்றுநோய் , நோய் எதிர்ப்பு சக்தி பதில் ,

Collagen plays protective role during pancreatic cancer development

Collagen plays protective role during pancreatic cancer development
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United States , Jiha Kim , Valeries Lebleu , Raghu Kalluri , Hikaru Sugimoto , Sujuan Yang , Yang Chen , Huamin Wang , Chang Jiun Wu , National Cancer Institute , University Of Texas Md Anderson Cancer Center , Cancer Prevention Research Institute Of Texas , Cancer Prevention , Research Institute , Cancer Biology , Translational Molecular Pathology , ஒன்றுபட்டது மாநிலங்களில் , ரகு கல்லூரி , யாங் சென் , தேசிய புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , புற்றுநோய் ப்ரெவெந்ஶந் ஆராய்ச்சி நிறுவனம் ஆஃப் டெக்சாஸ் , புற்றுநோய் ப்ரெவெந்ஶந் , ஆராய்ச்சி நிறுவனம் , புற்றுநோய் உயிரியல் , மொழிபெயர்ப்பு மூலக்கூறு நோயியல் ,

Pathologist Maryam Zenali, MD joins SVMC

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BENNINGTON â Maryam Zenali, MD, has joined Southwestern Vermont Medical Center Pathology and Dartmouth-Hitchcock Putnam Physicians, SVMC has announced.
Zenali earned her medical degree at the University of Texas Medical School and her bachelorâs degree in biology from the University of Houston. She completed her residency at the University of Texas Medical School and two fellowships â one in surgical pathology and a second in biomarker, combined with gastroenterology pathology, research â both at the University of Texas MD Anderson Cancer Center. She is board certified in surgical pathology and clinical pathology.
Most recently, Zenali worked as an anatomic pathologist within the Department of Pathology and Laboratory Medicine at the University of Vermont Medical Center. ....

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Cancer 'guardian' breaks bad with one switch

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IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone.
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Credit: Kolomeisky Research Group/Rice University
HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called the guardian of the genome, is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors. ....

University Of Houston , United States , Rice University , University Of Texas , David Yang , Navin Varadarajan , Aram Davtyan , Stephen Greenwell , Michelle Barton , Mohsen Fathi , Arash Saeedi , Mike Williams , Alena Klindziuk , Peter Vekilov , Jeff Falk , Michael Sherman , Kolomeisky Research Group Rice University , Rice Department Of Chemistry , National Science Foundation , Kolomeisky Research Group , University Of Texas Medical Branch At Galveston , Anatoly Kolomeisky At Rice University , Baker Institute For Public , Oregon Health Science University , Research Institute Of Texas , University Of Texas Md Anderson Cancer Center ,

Proteomics analysis identifies potential drug targets for aggressive human cancers

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Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets. They report in the journal
Oncogene, the identification of proteomic signatures that are associated with clinical measures of aggressive disease for each of the seven cancer types studied. Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets.
There are two notable aspects of this study. One is that we explored the proteomic landscape of cancer looking for proteins that were expressed in association with aggressive forms of cancer, said co-corresponding author Dr. Chad Creighton, professor of medicine and co-director of Cancer Bio ....

United States , Baylor College Of Medicine , Darshans Chandrashekar , Yiqun Zhang , Diana Monsivais , Sooryanarayana Varambally , Yasmin Vasquez , Ramyap Masand , Fengju Chen , Johnc Faver , Michaele Scheurer , Martinm Matzuk , Burroughs Wellcome Fund , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Clinical Proteomic Tumor Analysis Consortium , Researchers At Baylor College Of Medicine , University Of Alabama At Birmingham , Cancer Prevention Research Institute Of Texas , Children Brain Tumor Tissue Consortium , Danl Duncan Comprehensive Cancer Center , Cancer Genome Atlas Consortium , Baylor College , Chad Creighton , Cancer Bioinformatics , Texas Children ,