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Pinpointing how cancer cells turn aggressive


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IMAGE: Researchers from the University of Pennsylvania used a novel technique based on the CRIPSR-Cas9 system to precisely track the lineage of cancer cells. They found that that one clone (represented.
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Credit: University of Pennsylvania
It s often cancer s spread, not the original tumor, that poses the disease s most deadly risk.
And yet metastasis is one of the most poorly understood aspects of cancer biology, says Kamen Simeonov, an M.D.-Ph.D. student at the University of Pennsylvania Perelman School of Medicine.
In a new study, a team led by Simeonov and School of Veterinary Medicine professor Christopher Lengner has made strides toward deepening that understanding by tracking the development of metastatic cells. Their work used a mouse model of pancreatic cancer and cutting-edge techniques to trace the lineage and gene expression patterns of individual cancer cells. They found a spectrum of aggression in the cells that a ....

Beth Martin , Jay Shendure , Kamen Simeonov , Meganl Clark , Christopher Lengner , Robertj Nogard , Aaron Mckenna , Benz Stanger , Shipley Foundation Program For Innovation , University Of Pennsylvania Perelman School Medicine , University Of Pennsylvania School Veterinary Medicine , National Institutes Of Health , School Of Veterinary Medicine , Perelman School Of Medicine , University Of Washington , School Of Arts Sciences , Dartmouth Geisel School Of Medicine , Blavatnik Family Fellowship In Biomedical Research , Allen Discovery Center , Penn Medical Science Training Program , Howard Hughes Medical Institute , Department Of Biomedical Sciences , Pennsylvania Perelman School , Veterinary Medicine , Cancer Cell , Biomedical Sciences ,

COVID-19: Dogs being trained to sniff out coronavirus in people


Bangkok: Bobby was a good boy. So was Bravo.
Angel was a good girl, and when she sat, furry hindquarters sliding a little on the tile floor, she raised a paw for emphasis, as if to say, it’s this cotton ball that my keen nose has identified, the one that smells like COVID-19.
The three Labradors, operating out of a university clinic in Bangkok, are part of a global corps of dogs being trained to sniff out COVID-19 in people. Preliminary studies, conducted in multiple countries, suggest that their detection rate may surpass that of the rapid antigen testing often used in airports and other public places. ....

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