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Wuhan lab leak: Why scientists are suddenly more interested in this Covid origin theory

Wuhan lab leak: Why scientists are suddenly more interested in this Covid origin theory
CNN
1 hr ago
Analysis by Zachary B. Wolf, CNN
© Hector Retamal/AFP/Getty Images/FILE
Members of the World Health Organization (WHO) team investigating the origins of the Covid-19 coronavirus, wearing protective gear are seen during their visit to the Hubei Center for animal disease control and prevention in Wuhan, China s central Hubei province on February 2, 2021. (Photo by Hector RETAMAL / AFP) (Photo by HECTOR RETAMAL/AFP via Getty Images)
The United States is closer than ever to beating Covid-19, with half the country vaccinated and more restrictions lifting. ....

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Compound in Indian Long Pepper Found to Work Against Brain Cancer in Animal Models

Piperlongumine, a chemical compound found in the Indian long pepper plant, is known to kill cancerous cells in many tumor types, including brain tumors, according to Penn Medicine.
Now, an international team, including researchers from the University of Pennsylvaniaâs Perelman School of Medicine, has illuminated one way in which the piperlongumine works in animal models â and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer, the university announced in a press release.
The researchers, whose findings were published this month in ACS Central Science, showed in detail how piperlongumine binds to â and hinders the activity of â a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. ....

University Of Pennsylvania Perelman School Medicine , Perelman School , Indian Long Pepper , Brain Cancer , Penn Medicine , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா பெரல்மேன் பள்ளி மருந்து , பெரல்மேன் பள்ளி ,

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2
preprint server, researchers from the United States report that two iminosugar glucosidase inhibitors have the ability to suppress the replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tissue culture – at concentrations of at least 100 times lower than required for cytotoxic effects.
As the coronavirus disease 2019 (COVID-19) pandemic marches on, new antiviral agents effective against SARS-CoV-2 are urgently needed, despite a growing availability of vaccines. Remdesivir is still the only drug fully licensed for the treatment of affected individuals, but its effectiveness is controversial.
Iminosugar glucosidase inhibitors have their role in various viral diseases (e.g., hepatitis B and Ebola), as they prevent the folding process of a range of viral N-linked glycoprotein. Furthermore, they are competitive inhibitors of the host endoplasmic reticular (E ....

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Rituximab Tops Mycophenolate Mofetil for Pemphigus Vulgaris

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Significantly more patients with moderate-to-severe pemphigus sustained their complete remission with rituximab (Rituxan) than with mycophenolate mofetil (MMF), a randomized trial showed.
At 1 year, 40% of patients treated with rituximab had sustained complete remission after ≥16 weeks off prednisone, as compared with 10% of patients randomized to MMF. Rituximab treatment was associated with a significantly reduced need for glucocorticoids and with a dramatic reduction in the number of disease flares.
Quality-of-life scores improved more with rituximab, but MMF was associated with fewer serious adverse events (SAEs), reported Victoria Werth, MD, of the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues in the ....

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Ohio's vaccine lottery is a game-show approach to incentivize people to get the COVID-19 shot. Will it work?

Ohio's vaccine lottery is a game-show approach to incentivize people to get the COVID-19 shot. Will it work?
cleveland.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from cleveland.com Daily Mail and Mail on Sunday newspapers.

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