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Investors to rethink how they value the company and shares have lost more than 40 of their value so far this year so we can now get the latest with eric delmore in new york erin. There is a big question about whether tesla is a car company or a tech company . Or a tech company . Exactly, it is the reversal or a tech company . Exactly, it is the reversal from or a tech company . Exactly, it is the reversal from what or a tech company . Exactly, it is the reversal from what we or a tech company . Exactly, it is the reversal from what we used l or a tech company . Exactly, it is. The reversal fro...

this is cnn breaking news. >> welcome to "the lead." i'm jake tapper. we start this hour with breaking news. israel says a new group of hostages has been freed. it includes an american citizen. we saw the red cross convoy leaving gaza and entering egypt. the idf says this group consists of 14 people headed right now to meet up with israeli forces. 48-year-old leat bamin is now the second american released since the start of this pause in the violence between israel and hamas. after we saw 4-year-old abigail edan released earlier this week. let's get right to cnn's oren lieberman who ...

that breaking news out of the capital and the attempted carjacking of a secret service vehicle happening last night in georgetown. agents protecting the president's granddaughter opened fire thwarting the carjacking. details coming right up. striking back with deadly force, the u.s. launching new air strikes of proxies in syria. asme owe dana perino. bill is off today. hi, mike. >> mike: i'm mike emanuel. "america's newsroom." sources say one of the american strikes killed at least half a dozen iranian-backed fighter after a flurry of attacks against american troops throughout the re...

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by cytoplasmic deposition of the nuclear TAR-binding protein 43 (TDP-43). Although cytoplasmic re-localization of TDP-43 is a key event in the pathogenesis of ALS/FTD, the underlying mechanisms remain unknown. Here, we identified a non-canonical interaction between 14-3-3θ and TDP-43, which regulates nuclear-cytoplasmic shuttling. Neuronal 14-3-3θ levels were increased in sporadic ALS and FTD with TDP-43 pathology. Pathogenic TDP-43 showed increased interaction with 14-3-3θ, resulting in cytoplasmic accu...

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