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AACR-NCI-EORTC 2023: From glycobiology to novel immunotherapeutic approaches

Increasing knowledge of the cancer glycome and the need for new options to overcome resistance to immune checkpoint inhibitors are leading to an expansion of glycoimmunology. Stanford University professor Carolyn Bertozzi demonstrated that cell-surface glycans may be tagged to become targetable glyco-immune checkpoints. ....

Carolyn Bertozzi , Stanford University , Palleon Pharmaceuticals Inc , E 602 , Glyco Immunotherapy , Aacr Nci Eortc 2023 , Metastatic Cancer ,

AACR-NCI-EORTC 2023: PVRIG, a novel target to watch in cancer

In recent years, the introduction of immune checkpoint inhibitors to the oncolytic pipeline has been a significant breakthrough in cancer treatment, but unfortunately some tumors respond only minimally. In a session dealing with emerging checkpoints beyond PD-1, CTLA-4 and LAG3, Drew Rasco from the START Center for Cancer Care depicted a new player on the ground of immunotherapeutic options. ....

Bristol Myers Squibb Co , Drew Rasco , Cancer Care , Immune Checkpoint Inhibitors , Com 701 , Aacr Nci Eortc 2023 , Start Center For Cancer Care ,

AACR-NCI-EORTC 2023: Understanding ecDNA to stop running in circles in cancer

Cancer treatments for targeting tumor amplifications lag behind those targeting point mutations – and part of the reason may be that amplifications often reside on extrachromosomal DNA (ecDNA). Since ecDNA was first described back in 1965 as minute chromatin bodies in brain cancer cells, the use of large-scale DNA sequencing techniques has revealed the presence of ecDNA across a wide range of cancer types. “The circular structure of ecDNA is associated with increased proto-oncogenic capacity in comparison to linear amplifications. Another key feature is that ecDNA does not contain centromeres,” Roel Verhaak, from Yale School of Medicine, told the audience in a session at the 2023 AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics in Boston. ....

United States , Roel Verhaak , Yale School Of Medicine , Yale School , Molecular Targets , Cancer Therapeutics , National Cancer Institute , Boundless Bio Inc , Bbi 825 , Extrachromosomal Dna , Aacr Nci Eortc 2023 ,