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THE ELECTRIC STAIRS Gary Marmorstein While Ed Ritter was on the land line with the manager of Mobility Lift and Elevator, he had to keep a finger in his other ear so he could hear above the noise of the giant vacuum cleaner upstairs. “I’m sorry, sir, could you repeat that?” “I asked, if I’m…
An email contained additional allegations about Marc Tessier-Lavigne’s Alzheimer’s research and the 2011 internal review that former colleagues allege uncovered falsification.
Ann Kennedy’s work shows how neuronal activity in the hypothalamus can fine-tune core animal behaviors.
Scientists discovered how a mislocated protein implicated in several neurodegenerative diseases affects another protein that’s needed for normal nerve cell functioning.
Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative disorders in which many cases are linked by mislocalization of the TDP-43 protein, where instead of being located in the nucleus of the cell where genes are activated, it forms aggregates outside the nucleus in multiple neurodegenerative diseases. Rare mutations in TDP-43 are known to cause ALS, but almost all cases of ALS show mislocalization of TDP-43.