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When cancer patients undergo chemotherapy, the dose of most drugs is calculated based on the patient's body surface area. This is estimated by plugging the patient's height and weight into an equation, dating to 1916, that was formulated from data on just nine patients.
To improve chemotherapy dosing, MIT engineers designed CLAUDIA, a way to continuously measure how much drug is in a patient’s system during hours-long infusion.
Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this pro
<p>MIT and other researchers developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.</p>
A new AI strategy can identify transporters used by different drugs. The approach has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.