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New RNA-sequencing method can help detect numerous modified small RNAs A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable. RNA plays a central role in decoding the genetic information in DNA to sustain an organism's life. It is generally known as the intermediate molecule used to synthesize proteins from DNA. Cells are full of RNA molecules in ...

Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing (PANDORA) is a new RNA sequencing method developed by scientists from the University of California, Riverside (UCR). Unlike Pandora’s box which refers to a source of endless complications or trouble arising from a single, simple miscalculation—this Pandora, may be a source of opportunity as it can help discover numerous modified small RNAs that were previously undetectable. The researchers have published their method and findings in the journal  “Although high-throughput RNA sequencing (RNA-seq) has greatly advance...