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Forkhead box O's potential therapeutic use in the treatment of COVID-19 In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease). This review work is posted in the journal, Open Biology, published by the Royal Society. While most of the individuals infected with SARS-CoV-2 manifest mild clinical symptoms, those with severe C...

Smoking and vaping increase ACE2 levels and virus spike binding in airway epithelium The continuing spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally has not only taken a great toll on human health but threatens the economic stability of the human race. SARS-CoV-2, which is the virus responsible for the coronavirus disease 2019 (COVID-19), is unpredictable in its effects, as it has the potential to cause devastating disease in some while leaving most individuals asymptomatic or with a very mild form of the infection. A new bioRxiv*preprint attempts to make s...

Researchers scour what is known to come up with a hypothesis of why blood clots can be a major problem in COVID-19

In a paper recently uploaded to the preprint server bioRxiv by Kirchhoff et al. (May 31st, 2021) it is demonstrated that a single mutation to the RaTG13 spike protein results in significantly greater affinity towards the human receptor, indicating that the presence of a positively charged amino group at this position better facilitates interaction with the human ACE2 receptor, and helping to identify other viruses with zoonotic potential.

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and mortality across the world. Other than flu-like symptoms of respiratory disease, SARS-CoV-2 infection can also cause systemic manifestations, leading to a wide range of pathologies, including thrombosis and microvascular injury and stroke, vascular system disruption, gastrointestinal complications, ocular and dermatological symptoms, cardiac and kidney pathologies, neurological manif...