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Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro ....
Klar, wenn man die Krankheit Covid-19 nicht als Risiko wahrnimmt, erscheint eine Impfung unnötig. Was stimmt: Die Mehrheit übersteht eine Coronavirus-Infektion, ohne in ein Krankenhaus zu müssen, Long Covid zu entwickeln oder gar an der Krankheit zu sterben. Das bedeutet aber nicht, dass Covid-19 harmlos ist. Das Risiko einer schweren Erkrankung steigt stark mit dem Alter an, aber die Infektion kann auch für jüngere Erwachsene und sogar für Kinder gefährlich sein. Der Anteil der Gestorbenen liegt laut Robert Koch-Institut (RKI) »zwischen nahezu null Prozent (jüngste Altersgruppen) bis etwa 10 bis 30 Prozent (80+ Jahre alte Personen; je nach Anzahl der Risikofaktoren)«. ....
email article So far, the response to this pandemic has been focused on addressing the acute manifestations of COVID-19 but that is only the tip of the iceberg. We must not ignore what s beneath the surface: the lingering health and mental health implications of long COVID. Long after the initial infection should have resolved, a substantial number of people infected with SARS-CoV-2 continue to experience lingering health problems. Some patients even experience the emergence of new problems they did not have during the acute phase of the infection. The constellation of clinical abnormalities that characterize this phase of the disease is now generally referred to as long COVID (or more officially, post-acute sequelae of SARS-CoV-2, or PASC for short). People with long COVID have been dubbed long haulers. In addition to being at risk of long COVID, people who survive the acute phase of the COVID-19 infection are also at increased risk of death. The death and suffe ....