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Implantable Pharmacy-On-a-Chip Now Under Fasttrack Development

July 6, 2021
By Deborah Borfitz
July 6, 2021 | A trio of universities are putting their heads together to engineer a wirelessly controlled bioelectronic implant intended to help soldiers adapt to new time zones or drastic changes in their work schedules by releasing peptide-based therapies to harmonize their central and peripheral circadian clocks. The solicitation came from the Defense Advanced Research Projects Agency (DARPA) and the timeline is ambitious, with a first-in-human safety study expected to begin by 2025, according to Jonathan Rivnay, principal investigator of the project and assistant professor of biomedical engineering at Northwestern University.
The project aims to create a Normalizing Timing of Rhythms Across Internal Networks of Circadian Clocks (aka NTRAIN) device, otherwise known as a “living pharmacy” that involves the engineering of cells that will secrete biologics based on an optoelectronic trigger and a communication signal f ....

Isaac Hilton , Blackrock Neurotech , Omid Veiseh , Jonathan Rivnay , Deborah Borfitz , Fredw Turek , Carnegie Mellon , Carnegie Mellon University , Northwestern Center , Defense Advanced Research Projects Agency , Massachusetts Institute Of Technology , Rice University , Broad Agency Announcement , Northwestern University , Normalizing Timing , Rhythms Across Internal Networks , Circadian Clocks , Advanced Acclimation , Protection Tool , Environmental Readiness , Massachusetts Institute , Agency Announcement , Circadian Biology , ஐஸ்யாக் ஹில்டன் , கார்னகி மெலந் , கார்னகி மெலந் பல்கலைக்கழகம் ,

Nanotechnology Now - Press Release: Implantable 'living pharmacy' could control body's sleep/wake cycles: Project receives DARPA contract worth up to $33 million over 4 1/2 years

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Home > Press > Implantable living pharmacy could control body s sleep/wake cycles: Project receives DARPA contract worth up to $33 million over 4 1/2 years
In this artistic illustration, a user with an NTRAIN implant and its accompanying external hub works in the field. The user inputs a desired time shift (due to shift work or travel across time zones). Based on cues from the bodys physiology, the external hub detects the users circadian rhythm, and triggers the implant to produce precisely-dosed peptide therapies.
Abstract:
Device will harness the same peptides the body makes to regulate sleep cycles ....

Karrie Fitzpatrick , Omid Veiseh , Phyllisc Zee , Florian Solzbacher , Tzahi Cohen Karni , Carnegie Mellon , Rob Franklin , Carl Olson , Josiah Hester , Jonathan Rivnay , Darcy Griffin , Peng Jiang , Guillermo Ameer , Isaac Hilton , Doug Weber , Martha Hotz Vitaterna , Amanda Morris , Blackrock Microsystems , Caleb Kemere , Fredw Turek , Jacob Robinson , Kaiyuan Yang , Arrowhead Pharmaceuticals To Webcast Fiscal , University Of Utah , Weinberg College Of Arts , Northwestern Mccormick School Of Engineering ,