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July 6, 2021 By Deborah Borfitz July 6, 2021 | A trio of universities are putting their heads together to engineer a wirelessly controlled bioelectronic implant intended to help soldiers adapt to new time zones or drastic changes in their work schedules by releasing peptide-based therapies to harmonize their central and peripheral circadian clocks. The solicitation came from the Defense Advanced Research Projects Agency (DARPA) and the timeline is ambitious, with a first-in-human safety study expected to begin by 2025, according to Jonathan Rivnay, principal investigator of the p...

New PK Model Takes Some Of The Guesswork Out Of Pediatric Dosing May 27, 2021   May 27, 2021 | A machine learning specialist at Aalto University (Finland) is one of the lead developers of an algorithm for determining drug dosing in children at various stages of maturation, which could one day aid in the design of pediatric clinical trials having a small number of participants. Methods for modeling developmental and physiological differences between children and adults are “quite limited” and, in some cases, can lead to false conclusions because there is too little da...

A Deep Dive On mRNA Vaccines February 11, 2021 By Deborah Borfitz February 11, 2021 | Messenger RNA (mRNA) vaccines were the focus of a symposium on COVID-19 vaccines held during last week’s COVID-19 and Cancer virtual meeting of the American Association for Cancer Research. To date, only two vaccines have received Emergency Use Authorization by the U.S. Food and Drug Administration and both are mRNA vaccines—one developed by Moderna and the other by Pfizer and BioNTech. Speaking on development of the Moderna vaccine was Randall N. Hyer, M.D., Ph.D., the company’s s...

February 4, 2021 By Deborah Borfitz February 4, 2021 | A computer scientist at The Ohio State University (OSU) recently demonstrated the potential of artificial intelligence to crunch real-world data and emulate randomized clinical trials, speeding the pace of drug repurposing. The initial use case was focused on preventing heart failure and stroke in patients with coronary artery disease, but the model could be applied to any disease with a definable outcome, says Ping Zhang, who leads the Artificial Intelligence in Medicine Lab at OSU.  Zhang is senior author of a recently pub...

February 2, 2021 By Deborah Borfitz February 2, 2021 | The Human Heredity and Health in Africa (H3Africa) Consortium is endeavoring to foster collaborative research on the world’s second-most populous continent, having spent the past decade bolstering the genomics research capacity here with 48 projects across 34 countries. Clinical geneticist and physician-scientist Neil Hanchard, M.D., Ph.D., through his academic position at Baylor College of Medicine, has, for example, been involved in a H3Africa-sponsored genomic study in children coinfected with HIV and tuberculosis whose ...