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The human genome needs updating. But how do we make it fair?

Healthcare’s standard genome is mostly based on one American. As we enter the era of personalised medicine, this bias has drawbacks for much of the world’s population

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In gene tied to growth, scientists see glimmers of human history

In gene tied to growth, scientists see glimmers of human history
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Africans begin to take the reins of research into their own genomes


(Graphic) K. Franklin/Science
Those databases will illuminate studies of human variation worldwide, in part because the great genomic diversity in Africans can uncover spurious links to medical conditions, explains Concepcion Nierras, an NIH Common Fund geneticist. For example, in Europeans a rare variant of a gene for a low-density lipoprotein that contributes to high cholesterol seemed to raise the risk of heart disease. But Fatumo and his colleagues found that among Africans, the variant was common even in those who did not have heart disease, suggesting it may not have clinical relevance. The 
Nature paper uncovered 54 such variants that now need re-evaluation.

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H3Africa Consortium Primes A Continent For Large-Scale Genomics Research


February 2, 2021
By Deborah Borfitz
February 2, 2021 | The Human Heredity and Health in Africa (H3Africa) Consortium is endeavoring to foster collaborative research on the world’s second-most populous continent, having spent the past decade bolstering the genomics research capacity here with 48 projects across 34 countries. Clinical geneticist and physician-scientist Neil Hanchard, M.D., Ph.D., through his academic position at Baylor College of Medicine, has, for example, been involved in a H3Africa-sponsored genomic study in children coinfected with HIV and tuberculosis whose principal investigator is based in Botswana.
Most recently, Hanchard was one of the senior authors on an H3Africa-sponsored study published in

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Dr. Neil Hanchard joins NHGRI as a clinical investigator


Dr. Neil Hanchard joins NHGRI as a clinical investigator
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Dr. Hanchard will lead the new Childhood Complex Disease Genomics Section.
The National Human Genome Research Institute (NHGRI) has appointed Neil Hanchard, M.D., Ph.D., as a clinical investigator within the Medical Genomics and Metabolic Genetics Branch (MGMGB) in the NHGRI Division of Intramural Research. Dr. Hanchard will head the Childhood Complex Disease Genomics Section within the MGMGB.
“We are delighted to welcome Neil Hanchard to the NHGRI Intramural Research Program,” said Dan Kastner, M.D., Ph.D., NHGRI's scientific director. “Neil and his team will bring new energy and academic vigor to studies of the genomics of African ancestral populations, health disparities in underrepresented populations and precision medicine. Neil is an intellectual giant who will bring his outstanding scientific track record to the institute.”

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Post-Doctoral Position Studying the Genomics of Complex Childhood

Post-Doctoral Position Studying the Genomics of Complex Childhood
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