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Gene Discovery Points to a New Form of Alzheimer's - Vimarsana News

Gene Discovery Points to a New Form of Alzheimer's

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Not Just a Biomarker: YKL-40 Links Glial Clock to Amyloidosis - Vimarsana News

Not Just a Biomarker: YKL-40 Links Glial Clock to Amyloidosis

22 Dec 2020 Many people with Alzheimer’s wake up frequently at night, nap excessively during the day, and lose their sense of time. Besides sleep cycles, the circadian clock also controls astrocyte and microglia activation, and knocking out one of the core clock genes, Bmal1, hastens plaque formation and promotes neuroinflammation and synaptic damage. Now, researchers led by Erik Musiek and Brian Lananna at Washington University in St. Louis report that Bmal1 regulates the gene for YKL-40, a marker of Alzheimer’s disease. Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammator...