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ما هي مخاطر الجمع بين أكثر من دواء في وقت واحد؟ bbc.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bbc.com Daily Mail and Mail on Sunday newspapers.
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New Generation of Mouse Models Better Mimics Tauopathy, Alzheimer's alzforum.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from alzforum.org Daily Mail and Mail on Sunday newspapers.
12 Mar 2021 The E4 allele of the apolipoprotein E, a strong risk factor for many neurodegenerative diseases, most prominently late-onset Alzheimer’s disease, upsets the balance of lipids within cells. Exactly how ApoE4 does this remains unclear. In the March 3 Science Translational Medicine, researchers led by Li-Huei Tsai at MIT found that in human astrocytes and microglia, ApoE4 increased the amount of unsaturated lipids, which then accumulated in lipid droplets. Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers. How exactly does ApoE4 lead to lipid imbalance in astrocytes? ....
22 Dec 2020 Many people with Alzheimer’s wake up frequently at night, nap excessively during the day, and lose their sense of time. Besides sleep cycles, the circadian clock also controls astrocyte and microglia activation, and knocking out one of the core clock genes, Bmal1, hastens plaque formation and promotes neuroinflammation and synaptic damage. Now, researchers led by Erik Musiek and Brian Lananna at Washington University in St. Louis report that Bmal1 regulates the gene for YKL-40, a marker of Alzheimer’s disease. Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammatory responses, promotes astrocyte and microglial phagocytosis of Aβ, and mitigates amyloid plaque formation at least in mice. The findings, reported in the December 16 Science Translational Medicine, connect the circadian clock to glial responses in AD. Oddly, YKL-40 itself seems to have no circadian rhythm. ....