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Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools-;previously developed to analyze brains of patients in the clinic-;to investigate Alzheimer's disease progression in preclinical animal models.
With the grant, IU will expand the research program with the goal of recreating genetic mutations in mice that are similar to those found in people with late-onset Alzheimer’s.
Most drugs developed to treat Alzheimer's disease have for years been ineffective in clinical trials. Researchers from Indiana University School of Medicine recently evaluated the efficacy of a failed clinical trial drug using their rigorous pipeline.
Taconic Biosciences suggests that preclinical findings may translate more readily to human patients if researchers use multiple models.