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Danone Canada Redefines the Plant-Based Category With Silk Nextmilk

Danone Canada Redefines the Plant-Based Category With Silk Nextmilk
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Droplets of Unsaturated Fats Burden Human ApoE4 Astrocytes


12 Mar 2021
The E4 allele of the apolipoprotein E, a strong risk factor for many neurodegenerative diseases, most prominently late-onset Alzheimer’s disease, upsets the balance of lipids within cells. Exactly how ApoE4 does this remains unclear. In the March 3 Science Translational Medicine, researchers led by Li-Huei Tsai at MIT found that in human astrocytes and microglia, ApoE4 increased the amount of unsaturated lipids, which then accumulated in lipid droplets. Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers.
How exactly does ApoE4 lead to lipid imbalance in astrocytes? ....

Norra Savolax , Grzegorz Sienski , Susan Lindquist , Priyanka Narayan , Hilkka Soininen , Julia Bonner , Li Huei Tsai , Alois Alzheimer , Helen Santoro , Danone Research , University Of Eastern Finland , Translational Medicine , Eastern Finland , Genotype Tissue Expression , Kyoto Encyclopedia , Available Further , சூசன் லிண்ட்கிஸ்ட் , பிரியாங்க நாராயண் , ஜூலியா பொன்னர் , அலோயிஸ் முதுமறதி , ஹெலன் சாண்டோரோ , பல்கலைக்கழகம் ஆஃப் கிழக்கு பின்லாந்து , மொழிபெயர்ப்பு மருந்து , கிழக்கு பின்லாந்து , கியோட்டோ கலைக்களஞ்சியம் , கிடைக்கிறது மேலும் ,