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CAR-T-cell shows promise in patients with lymphoma of brain and spinal cord in early trial

CAR-T-cell shows promise in patients with lymphoma of brain and spinal cord in early trial
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United States , Dana Farber Cancer Institute , Dana Farber Caron Jacobson , James Kaminski , Leslie Kean , Dana Farber Ulrike Gerdemann , Alexandre Albanese , American Society Of Hematology , Broad Institute , Systems Immunology Lab , American Society , Cellular Therapeutics , Boston Children , Caron Jacobson , Ulrike Gerdemann ,

"SCOUT" helps researchers find, quantify significant differences among organoids | MIT News


Caption:
This cross-section of an organoid processed with SCOUT shows cells labeled with various antibodies to highlight different cell types: cell nuclei are in blue (DAPI dye), glia/neural progenitor nuclei are in red (anti-SOX2), glia/neural progenitor projections are in green (anti-vimentin), neuronal projections are in white (anti-B3-tubulin).
Credits:
Image courtesy of the Chung lab.
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The ability to culture cerebral organoids, or “minibrains,” using stem cells derived from people has given scientists experimentally manipulable models of human neurological development and disease, but not without confounding challenges. No two organoids are alike and none of them resemble actual brains. This “snowflake” problem has held back the science by making scientifically meaningful quantitative comparisons difficult to achieve. To help researchers overcome those ....

Dae Hee Yun , Nicholasb Evans , Silvia Velasco , Kwanghun Chung , Justin Swaney , Paola Arlotta , Alexandre Albanese , Jennam Antonucci , Lee Gehrke , Cultural Foundation , Harvard University , Institute For Medical Engineering , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Unbiased Techniques , Associate Professor Kwanghun , Picower Institute , Medical Engineering , Chemical Engineering , Helmholtz Professor , National Institutes , டே ஹீ யுன் , சில்வியா வெலாஸ்கோ , ஜஸ்டின் ஸ்வானே , அலெக்ஸாண்ட்ரே அல்பானீஸ் ,