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As Plan S Takes Effect, Some Anticipate Inequitable Outcomes

As Plan S Takes Effect, Some Anticipate Inequitable Outcomes
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Sao Paulo , United States , South Africa , Robin Crewe , Robert Kiley , Nikiwe Momoti , Alicia Kowaltowski , Ahmed Ogunlaja , Academy Of Science South Africa , European Commission , University Of Pretoria , National Agricultural Technology Institute , European Research Council , Washington University In St , African Medical Research Council , University Of Sao Paulo , European Research , Journal Citation Reports , South African Medical Research Council , Springer Nature , Humberto Debat , National Agricultural Technology , Wellcome Trust , Global Equity Model , Washington University , Latin America ,

Study helps understand why kids of obese mothers may be susceptible to metabolic diseases

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IMAGE: Image of a mitofusin-2 deficient egg shows mitochondria [stained green] to be fewer, more aggregated, and swollen than in controls
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Credit: Marcos Chiaratti
A Brazilian study published in the journal
Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.
According to the authors, transgenerational transmission of metabolic diseases may be associated with Mfn2 deficiency in the mother s oocytes (immature eggs). Mfn2 refers to mitofusin-2, a protein involved in the regulation of vascular smooth muscle cell proliferation. It is normally found in the outer membrane of mitochondria, the organelles that supply cells with energy. A deficiency leads to mitochondrial swelling and dysfunction, as well as altering the expression of almost 1,000 genes in female gametes. ....

Bruna Garcia , Carlos Ufscar , Alicia Kowaltowski , Marcos Chiaratti , Dissemination Centers Ridcs , Comorbidities Research Center , Paulo Research Foundation , Research On Redox Processes In Biomedicine Redoxome , Ufscar Center , Paulo Chemistry Institute , Health Sciences , Molecular Human Reproduction , Federal University , Redox Processes , Dissemination Centers , Chemistry Institute , புருனா கார்சியா , பாலொ ஆராய்ச்சி அடித்தளம் , பாலொ வேதியியல் நிறுவனம் , ஆரோக்கியம் அறிவியல் , மூலக்கூறு மனிதன் இனப்பெருக்கம் , கூட்டாட்சியின் பல்கலைக்கழகம் , ரெடாக்ஸ் ப்ரோஸெஸஸ் , பரப்புதல் மையங்கள் , வேதியியல் நிறுவனம் ,