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New MIT professors research hibernation, cancer, the immune system, airways, and human movement in the departments of biology and brain and cognitive sciences at the School of Science.
A cancer link to obesity: A metabolic tug-of-war The Harvard Gazette Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival. Over the years, scientists have identified obesity-related processes that drive tumor growth, such as metabolic changes and chronic inflammation, but a detailed understanding of the interplay between obesity and cancer has remained elusive. Now, in a study in mice, Harvard Medical School (HMS) researchers have uncovered a new piece of this puzzle, with surprising implications for cancer immunotherapy...
Obesity Impairs Immune Cell Function in Cancer, Triggers Tug-of-War for Fuel December 10, 2020 Source: Science Artwork/Science Photo Library/Getty Images Research by a Harvard Medical School (HMS)-led research team has uncovered a new mechanism by which obesity can interfere with the immune system’s ability to fight cancer. Their studies demonstrated how, in tumor-bearing mice fed a high-fat diet, cancer cells reprogram their metabolism in response to the increased fat availability, so they can better consume energy-rich fat molecules, which then deprives tumor-killing T cells of fuel and a...
Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival.