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Study shows how certain cancers neutralize T cells to subvert immune system and help tumors grow

Study shows how certain cancers neutralize T cells to subvert immune system and help tumors grow
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Dana-farber-cancer-institute , Massachusetts , United-states , Gregory-baker , Jefte-drijvers , Arlene-sharpe , Heide-baron , Alison-ringel , Bruker-daltonics , Jia-ren-lin , Nathalie-agar , Gerard-baquer

Disarming body's defenders | Mirage News

Disarming body's defenders | Mirage News
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Dana-farber-cancer-institute , Massachusetts , United-states , Gregory-baker , Jefte-drijvers , Arlene-sharpe , Heide-baron , Alison-ringel , Bruker-daltonics , Jia-ren-lin , Nathalie-agar , Gerard-baquer

Seven new faculty join the MIT School of Science

New MIT professors research hibernation, cancer, the immune system, airways, and human movement in the departments of biology and brain and cognitive sciences at the School of Science.

Alison-ringel , Nidhi-seethapathi , Sara-prescott , Hernandez-moura-silva , Koch-institute , Whitehead-institute-for-biomedical-research , Ragon-institute , Ohio-state-university , Department-of-electrical-engineering , Veermata-jijabai-technological-institute , Harvard-university , Rockefeller-university

A cancer link to obesity: A metabolic tug-of-war - INDIA New England News

A cancer link to obesity: A metabolic tug-of-war
The Harvard Gazette
Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival. Over the years, scientists have identified obesity-related processes that drive tumor growth, such as metabolic changes and chronic inflammation, but a detailed understanding of the interplay between obesity and cancer has remained elusive.
Now, in a study in mice, Harvard Medical School (HMS) researchers have uncovered a new piece of this puzzle, with surprising implications for cancer immunotherapy: Obesity allows cancer cells to outcompete tumor-killing immune cells in a battle for fuel.

Cong-hui-yao , Vikram-juneja , Gregory-baker , Arlene-sharpe , Jefte-drijvers , Alison-ringel , Thao-nguyen , Marcia-haigis , Steven-gygi , Haejin-yoon , Justin-trombley , Juan-garc

Obesity Impairs Immune Cell Function in Cancer, Triggers Tug-of-War for Fuel

Obesity Impairs Immune Cell Function in Cancer, Triggers Tug-of-War for Fuel
December 10, 2020
Source: Science Artwork/Science Photo Library/Getty Images
Research by a Harvard Medical School (HMS)-led research team has uncovered a new mechanism by which obesity can interfere with the immune system’s ability to fight cancer. Their studies demonstrated how, in tumor-bearing mice fed a high-fat diet, cancer cells reprogram their metabolism in response to the increased fat availability, so they can better consume energy-rich fat molecules, which then deprives tumor-killing T cells of fuel and accelerates tumor growth. The cancer cells effectively outcompete the immune cells in the battle for fuel, leading to reduced numbers and activity of CD8+ T cells in the tumor microenvironment (TME). Because CD8+ T cells are the main weapon used by immunotherapies that activate the immune system against cancer, the study results could point to potential new strategies for improving these treatment approaches.

United-states , Marcia-haigis , Arlene-sharpe , Jefte-drijvers , Alison-ringel , George-fabyan , Harvard-medical-school , Science-artwork-photo-library-getty-images , Blavatnik-institute , Science-photo , Shapes-metabolism , Tumor-microenvironment

Study provides a detailed understanding of the interplay between obesity and cancer

Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival.

Marcia-haigis , Arlene-sharpe , Jefte-drijvers , Alison-ringel , Emily-henderson , Harvard-medical-school , Department-of-immunology , Blavatnik-institute , Fabyan-professor , Comparative-pathology , மார்சியா-ஹைகிஸ் , அர்லேனே-கூர்மையான