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Promising Drug Candidate Shows Potential to 'Unmask' Latent HIV-Infected Cells, Targeting them for Elimination – India Education | Latest Education News | Global Educational News

Promising Drug Candidate Shows Potential to 'Unmask' Latent HIV-Infected Cells, Targeting them for Elimination – India Education | Latest Education News | Global Educational News
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Blocking viruses' exit strategy

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IMAGE: Marburg virus-like-particles (in green, which are not infectious) "bud, " or exit from the surface of a host cell. A host protein (in yellow) helps the VLPs bud. Research by Penn...
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Credit: Penn Vet Microscopy Core Facility
The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.
A team of researchers is working to change that. In a new paper in the journal
Antimicrobial Agents and Chemotherapy, investigators from Penn's School of Veterinary Medicine, working together with scientists from the Fox Chase Chemical Diversity Center and the Texas Biomedical Research Institute, report encouraging results from tests of an experimental antiviral targeting Marburg virus. The compound blocks the virus from departing infected cells, thus putting the brakes on the spread of infection. Their findings are the first to show that this novel class of inhibitors can be effective against the infection in an animal model.

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