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Innovations Needed and Future Directions in Treatment of NSCLC

Concluding thoughts on data presented at ESMO 2023, and innovations still needed for improved survival of NSCLC provided by Patrick Forde, MBBCh. ....

Patrick Forde , Post Conference Perspectives , Adjuvant Targeted Therapy , Docetaxel Chemotherapy , Platinum Doublet Chemotherapy , Tropion Lung01 , Egfr Mutation , Mariposa Trial , Egfr Tki , Mariposa 2 ,

PAPILLON Trial Insights: ESMO 2023

Patrick Forde, MBBCh, discusses advances in EGFR Exon 20 insertion-mutated NSCLC. ....

Patrick Forde , Post Conference Perspectives , Egfr Exon 20 , Infusion Related Reactions ,

Amivantamab Plus Chemotherapy with and without Lazertinib in EGFR-mutant NSCLC

1. Progression-free survival was 6.3 months for the amivantamab–chemotherapy group, 8.3 months for the amivantamab–lazertinib–chemotherapy group, and 4.2 months for the chemotherapy group. 2. Adverse events grade 3 or higher occurred in 72% vs 92% vs 48% respectively, with the most common adverse events being neutropenia, thrombocytopenia, anemia, and leukopenia Evidence Rating Level: 1 (Excellent) ....

Rating Level , Egfr Lung Cancer , Chronic Disease ,

COMING SOON: Amivantamab + Lazertinib Versus Osimertinib as 1L Treatment in EGFR-Mutated Advanced NSCLC: Primary Results From MARIPOSA

Expert oncologist Alex Spira, MD, PhD, FACP, shares his excitement for an upcoming program centered on the MARIPOSA study in advanced NSCLC following the ESMO 2023 annual meeting. ....

Lazertinib Versus Osimertinib , Mutated Advanced , Primary Results From , Non Small Cell Lung Cancer , Advanced Nsclc , Metastatic Nsclc , Mariposa Trial , Mariposa Study , Egfr Mutated , Egfr Mutant , Combination Therapy , Novel Therapy , Egfr Tki , Tyrosine Kinase Inhibitors , Met Inhibitor , Chrysalis Study , Chrysalis Trial , Exon 20 , Egfr L858r , Efficacy Data , Overall Survival , Progression Free Survival , Pfs Data , Cns Disease , Brain Metastases , Safety Data ,

Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions

1. Median progression-free survival was 11.4 months in the amivantamab–chemotherapy group and 6.7 months in the chemotherapy group with HR 0.40. 2. Serious adverse events occurred in 37% of the amivantamab–chemotherapy group and 31% of the chemotherapy group. Evidence Rating Level: 1 (Excellent) Study Rundown: Exon 20 insertions are the third most common mutation in ....

Rating Level , Egfr Lung Cancer , Exon 20 , Chronic Disease ,