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Transcriptional regulator BRD2 as a potential therapeutic target for COVID-19

A team of international scientists has demonstrated that therapeutic inhibition of a transcriptional regulator BRD2, required for the endogenous expression of angiotensin-converting enzyme 2 (ACE2), can potentially suppress severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the bioRxiv preprint server. ....

Sanchari Sinha Dutta , World Health Organization , World Health , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , சஞ்சரி சீன்ஹா தத்தா , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , உலகம் ஆரோக்கியம் , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide. ....

Rupal Bhatt , Thomas Walther , Emily Henderson , University College Cork , Beth Israel Deaconess Medical Center , Harvard Medical School , Science Translational , Harvard Medical , Renal Cell Carcinoma , Kidney Cancer , ரூபல் பட் , தாமஸ் வால்டர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் கல்லூரி கார்க் , பெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம் , ஹார்வர்ட் மருத்துவ பள்ளி , அறிவியல் மொழிபெயர்ப்பு , ஹார்வர்ட் மருத்துவ , சிறுநீரகம் செல் புற்றுநோய் , கிட்நீ புற்றுநோய் ,

ACE2 and furin levels linked to higher levels of inflammation in smokers with COVID-19

A new study reports the level of ACE2 and furin, two enzymes that are intimately linked to infection with SARS-CoV-2, the causative agent of COVID-19. ....

Liji Thomas , Sergii Sobolevskyi Shutterstock , Sergii Sobolevskyi , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Diabetes Mellitus , Heart Disease , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , நீரிழிவு நோய் , நீரிழிவு நோய் மெல்லிடஸ் , இதயம் நோய் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Two common blood pressure drugs are not tied to increased risk of COVID-19

Two common blood pressure drugs are not tied to increased risk of COVID-19
Research published in the peer-reviewed journal
The Lancet Digital Health and co-led by a UCLA Fielding School of Public Health faculty member has found that two widely used types of blood pressure drugs are not tied to an increased risk of COVID-19 infection or complications.
The international team co-led by Dr. Marc Suchard, UCLA Fielding School professor of biostatistics, found that there was no increased risk of COVID-19 diagnosis, hospitalization, or subsequent complications for users of either angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs). The study, the world s largest, examined a group of more than 1.1 million patients in the United States and Spain using antihypertensives, researchers said. ....

United States , United Kingdom , Marc Suchard , George Hripcsak , Daniel Morales , Emily Henderson , Yale University , Observational Health Data Services , Columbia Department Of Biomedical Informatics , University Of Oxford , Columbia University , Fielding School Of Public Health , Lancet Digital Health , Fielding School Professor Of Biostatistics , Fielding School , Columbia Data Science Institute , University Of Dundee , Public Health , School Professor , Wellcome Trust , Columbia Department , Biomedical Informatics , Columbia Data Science , Blood Pressure , Ace Inhibitor , ஒன்றுபட்டது மாநிலங்களில் ,

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals. ....

South Africa , United States , United Kingdom , South African , Image Credit , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , படம் கடன் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,