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UPMC: Blood Thinners Reduce Need for Cardiovascular and Respiratory Support in Certain COVID-19 Patients

Giving moderately ill, hospitalized COVID-19 patients a full dose of a blood thinner improved their chances of leaving the hospital without needing mechanical ventilation. But this strategy did not yield the same results for COVID-19 patients who wer ....

Robertag Simmons , Judith Hochman , Bryan Mcverry , Matthewd Neal , Stephen Wisniewski , Grossman School Of Medicine , University Of Pittsburgh School Medicine , Adaptive Platform Trial For Community , Pitt Division Of Pulmonary , Pitt Epidemiology Data Center , Pitt Graduate School Of Public Health , New England Journal , Randomized Controlled Platform Trial , Antithrombotic Strategies , Hospitalized Adults , Ameliorate Complications , Multi Factorial Adaptive Platform Trial , Pittsburgh School , Critical Care , Epidemiology Data Center , Maria Mori Brooks , Graduate School , Harold Snyder Family Professor , Antithrombotics Inpatient , Associate Professor ,

Initiating therapeutic anticoagulation benefits moderately ill COVID-19 patients, but not critically ill patients

A large clinical trial conducted worldwide shows that treating moderately ill hospitalized COVID-19 patients with a full-dose blood thinner reduced their need for organ support, such as mechanical ventilation, and improved their chances of leaving the hospital. ....

United States , Robertag Simmons , Judith Hochman , Matthewd Neal , Garyh Gibbons , Emily Henderson , National Health , Clinical Sciences At New York University , National Institutes Of Health , Adaptive Platform Trial For Community , Canadian Institutes Of Health Research , National Institute For Health Research , University Of Pittsburgh , Research Council Australia , York University , National Heart , Blood Institute , National Institutes , New England Journal , Clinical Sciences , New York University , Antithrombotics Inpatient , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotic Therapy ,

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients
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NIH Pauses Anticoagulant Trial For Critically Ill COVID-19 Patients

NIH Pauses Anticoagulant Trial For Critically Ill COVID-19 Patients
Therapeutic anticoagulation trials is looking at which blood thinners are best to use to treat COVID-caused venous thrombosis embolism (VTE)
Thrombus formation in the aortic arch in a 46-year-old COVID patients in the ICU. Three trials are underway to find which anticoagulant strategy is best to treat moderate and critically ill patients where COVID-causes venous thrombo-embolism (VTE) is a major cause of complications. Image courtesy of Margarita Revzin et al.
December 23, 2020 Three clinical trial platforms working together to test the effects of full doses of anticoagulants in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 (SARS-CoV-2) patients requiring intensive care unit (ICU) support, therapeutic anticoagulation drugs did not reduce the need for organ support. Enrollment continues for moderately ill hospitalized COVID-19 patients in the tri ....

United States , New York , New York University , Margarita Rezvin , National Health , National Institutes Of Health , Adaptive Platform Trial For Community , Canadian Institutes Of Health Research , National Institute For Health Research , University Of Pittsburgh , Research Council Australia , York University , National Heart , Blood Institute , Widespread Blood Clots , Trials Looking , Anticoaguation Strategies , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotics Inpatient , Antithrombotic Therapy , Ameliorate Complications , Canadian Institutes , Health Research , National Institute ,

International trials of blood thinners in critically ill COVID-19 patients pause due to futility

International trials of blood thinners in critically ill COVID-19 patients pause due to futility
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Ryan Zarychanski , Ewan Goligher , University Of Toronto , Hospital Research Institute , University Health Network , Adaptive Platform Trial For Community , University Of Manitoba , Cancercare Manitoba , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotics Inpatient , Antithrombotic Therapy , Ameliorate Complications , Toronto General Hospital Research Institute , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , மருத்துவமனை ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆரோக்கியம் வலைப்பின்னல் , மாற்றி அமைக்கத்தக்க நடைமேடை சோதனை க்கு சமூக , பல்கலைக்கழகம் ஆஃப் ம்யாநிடோப , புற்றுநோய் ம்யாநிடோப , சமூக வாங்கியது நூமோநிய , சிகிச்சை எதிர்விளைவு , டொராண்டோ ஜநரல் மருத்துவமனை ஆராய்ச்சி நிறுவனம் ,