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Cureus | COVID-19 Demonstrates That Inflammation Is a Hyperviscous State

Many of the complications of severe coronavirus disease-2019 (COVID-19) are caused by blood hyperviscosity driven by marked hyperfibrinogenemia. This results in a distinctive hyperviscosity syndrome which affects areas of high and low shear. A change in blood viscosity causes a threefold inverse change in blood flow, which increases the risk of thrombosis in both arteries and veins despite prophylactic anticoagulation. Increased blood viscosity decreases perfusion of all tissues, including the lungs, heart, and brain. Decreased perfusion of the lungs causes global ventilation-perfusion mismatch which results in silent hypoxemia and decreased efficacy of positive pressure ventilation in treating pulmonary failure in COVID-19. Increased blood viscosity causes a mismatch in oxygen supply and demand in the heart, resulting in myocarditis and ventricular diastolic dysfunction. Decreased perfusion of the brain causes demyelination because of a sublethal cell injury to oligodendrocytes. Hy ....

Holger Schmid , Adaptive Platform Trial For Community , Holger Schmid Sch , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Antithrombotic Therapy , Ameliorate Complications , Central Nervous ,

UPMC: Blood Thinners Reduce Need for Cardiovascular and Respiratory Support in Certain COVID-19 Patients

Giving moderately ill, hospitalized COVID-19 patients a full dose of a blood thinner improved their chances of leaving the hospital without needing mechanical ventilation. But this strategy did not yield the same results for COVID-19 patients who wer ....

Robertag Simmons , Judith Hochman , Bryan Mcverry , Matthewd Neal , Stephen Wisniewski , Grossman School Of Medicine , University Of Pittsburgh School Medicine , Adaptive Platform Trial For Community , Pitt Division Of Pulmonary , Pitt Epidemiology Data Center , Pitt Graduate School Of Public Health , New England Journal , Randomized Controlled Platform Trial , Antithrombotic Strategies , Hospitalized Adults , Ameliorate Complications , Multi Factorial Adaptive Platform Trial , Pittsburgh School , Critical Care , Epidemiology Data Center , Maria Mori Brooks , Graduate School , Harold Snyder Family Professor , Antithrombotics Inpatient , Associate Professor ,

Initiating therapeutic anticoagulation benefits moderately ill COVID-19 patients, but not critically ill patients

A large clinical trial conducted worldwide shows that treating moderately ill hospitalized COVID-19 patients with a full-dose blood thinner reduced their need for organ support, such as mechanical ventilation, and improved their chances of leaving the hospital. ....

United States , Robertag Simmons , Judith Hochman , Matthewd Neal , Garyh Gibbons , Emily Henderson , National Health , Clinical Sciences At New York University , National Institutes Of Health , Adaptive Platform Trial For Community , Canadian Institutes Of Health Research , National Institute For Health Research , University Of Pittsburgh , Research Council Australia , York University , National Heart , Blood Institute , National Institutes , New England Journal , Clinical Sciences , New York University , Antithrombotics Inpatient , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotic Therapy ,

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Ryan Zarychanski , Alistair Nichol , Ewan Goligher , Alistair Nicholsaid , University Of Toronto , Irish Critical Care Clinical Trials Network , Ucd School Of Medicine , Health Research Board , Intensivist At St Vincent University Hospital , Adaptive Platform Trial For Community , New England Journal , Associate Professor , Internal Medicine , Cancercare Manitoba , Therapeutic Anticoagulation , Antithrombotic Therapy , Ameliorate Complications , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Patrick Lawler , Peter Munk Cardiac Centre , University Health Network , Toronto General Hospital , Critical Care Medicine , Professor Alistair Nicholsaid , Irish Critical Care Clinical Trails Network ,

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients
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United States , Robertag Simmons , Judith Hochman , Matthewd Neal , Garyh Gibbons , Clinical Sciences At New York University , National Health , Us Department Of Health , Human Services , National Institutes Of Health , Adaptive Platform Trial For Community , Discovery Into Health , Canadian Institutes Of Health Research , National Institute For Health Research , University Of Pittsburgh , Research Council Australia , York University , Blood Institute , National Heart , National Institutes , New England Journal , Clinical Sciences , New York University , Antithrombotics Inpatient , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia ,