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Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada

Background: Between February and June 2021, the initial wild-type strains of SARS-CoV-2 were supplanted in Ontario, Canada, by new variants of concern (VOCs), first those with the N501Y mutation (i.e., Alpha/B1.1.17, Beta/B.1.351 and Gamma/P.1 variants) and then the Delta/B.1.617 variant. The increased transmissibility of these VOCs has been documented, but knowledge about their virulence is limited. We used Ontario’s COVID-19 case data to evaluate the virulence of these VOCs compared with non-VOC SARS-CoV-2 strains, as measured by risk of hospitalization, intensive care unit (ICU) admission and death.

Methods: We created a retrospective cohort of people in Ontario who tested positive for SARS-CoV-2 and were screened for VOCs, with dates of test report between Feb. 7 and June 27, 2021. We constructed mixed-effect logistic regression models with hospitalization, ICU admission and death as outcome variables. We adjusted models for age, sex, time, vaccination status, comorbiditie ....

United Kingdom , Ashleigh Tuite , David Fisman , Public Health Ontario Laboratory , World Health Organization , University Of Toronto , Elementary Teachers Federation Of Ontario , Canadian Institutes For Health Research , Research Ethics Board , Public Health Ontario , Nurses Association Of Ontario , Between February , Observational Studies , Ontario Case , Contact Management , Greater Toronto , Hamilton Area , Elementary Teachers Federation , Registered Nurses Association , Canadian Institutes , Health Research , Open Access , Creative Commons Attribution ,