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Hypoxia signaling pathway could lead to COVID-19 treatments Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19). The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypoxic conditions reduced expression of angiotensin-converting enzyme 2 (ACE2) – the primary host cell receptor required for viral attachment and entry. They als...