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Hypoxia signaling pathway could lead to COVID-19 treatments
Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).
The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Hypoxic conditions reduced expression of angiotensin-converting enzyme 2 (ACE2) – the primary host cell receptor required for viral attachment and entry. They also decreased the expression of heparan sulfate (HS), another receptor known to be required for SARS-CoV-2 attachment.
The team – from the Basque Research and Technology Alliance in Derio and the Basque Foundation for Science in Bilbao also showed that hypoxia decreased HS levels through reduced expression of the main HS-containing proteoglycans (HSPGs) – syndecan-1 and synde ....

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