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Deletions in SARS-CoV-2 Spike protein drive antibody escape


Researchers have found that SARS-CoV-2 evades immune responses by deleting parts of its genetic sequence that encode for the Spike protein.
According to a new study, SARS-CoV-2 evades immune responses by selectively deleting small bits of its genetic sequence. The study was conducted at the University of Pittsburgh School of Medicine, US.
The researchers say that since these deletions happen in a part of the sequence that encodes for the shape of the Spike (S) protein, a formerly neutralising antibody cannot bind to the virus. Furthermore, because the molecular “proofreader” that usually catches errors during SARS-CoV-2 replication is “blind” to fixing deletions, they become cemented into the variant’s genetic material. ....

United Kingdom , Paul Duprex , Kevin Mccarthy , University Of Pittsburgh School Medicine , Pittsburgh School , Assistant Professor Kevin , ஒன்றுபட்டது கிஂக்டம் , கெவின் ம்க்கார்தீ , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , பிட்ஸ்பர்க் பள்ளி , உதவியாளர் ப்ரொஃபெஸர் கெவின் ,